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KMID : 0361120180320030049
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Korean Journal of Transplantation
2018 Volume.32 No. 3 p.49 ~ p.56
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The Effect of Bortezomib on the Management of Immediate Postoperative Refractory Antibody-Mediated Rejection after Kidney Transplantation
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Kim So-Jeong
Jun Kang-Woong
Hwang Jeong-Kye
Chung Byung-Ha
Yang Chul-Woo
Moon In-Sung
Kim Ji-Il
Kim Mi-Hyeong
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Abstract
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Background: Bortezomib has been used to treat antibody-mediated rejection (AMR) that usually develops after kidney transplantation (KT). Although it has been used in various clinical situations, it is difficult to precisely define how the drug affects the clinical course. We used bortezomib to treat eight cases of AMR that developed immediately following KT in patients who were resistant to conventional treatment.
Methods: Eight cases of refractory AMR that developed immediately after KT were treated with bortezomib on days 1, 4, 8, and 11.
Results: The resolution rate was 75%, and the 2-year rejection-free survival rate was 83%. Six cases underwent immunologically high-risk KT. Six recovering patients exhibited clinical improvement within 2 weeks of the first dose of bortezomib and recovered completely within 2 months. The effects of bortezomib seemed to be prolonged; only one additional rejection episode was observed. The two failed patients never exhibited any clinical improvement and progressed aggressively to graft failure soon after transplantation. Their donor specific anti-human leukocyte antigen antibody were sustained at high levels.
Conclusions: Bortezomib is an effective rescue therapy in patients with AMR that developed immediately after KT.
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KEYWORD
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Bortezomib, Graft rejection, Immunosuppression, Kidney transplantation
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